Dr. Mosconi completed his Ph.D. in Clinical Psychology and an APA-approved Clinical Internship at the University of North Carolina – Chapel Hill. He then performed his postdoctoral training in developmental cognitive neuroscience and pediatric neuropsychology at the University of Illinois in Chicago. Dr. Mosconi joined the faculty in Psychiatry at the University of Illinois in Chicago from 2009-2011, moved onto the faculty at the University of Texas Southwestern Medical Center from 2011-2015, and joined the faculty at the University of Kansas in August, 2015. He currently is the Director of the Kansas Center for Autism Research and Training (K-CART), Associate Professor of Psychology and Applied Behavioral Science, and Associate Scientist in the Life Span Institute. Dr. Mosconi’s research is focused on sensorimotor dysmaturation and underlying brain mechanisms in neurodevelopmental disorders, including autism spectrum disorder, Phelan-McDermid Syndrome, and FMR1 related disorders. His work has been supported by NIH (NIMH, NINDS, NICHD), the Department of Defense, Autism Speaks, the Phelan-McDermid Syndrome Foundation and the Once Upon A Time Foundation. He has published in multiple high impact journals including JAMA Psychiatry, the Journal of Neuroscience, Journal of Neurophysiology, Molecular Autism, NeuroImage and Biological Psychiatry. Dr. Mosconi serves on the editorial boards of the Journal of Autism and Developmental Disorders Research in Autism Spectrum Disorders, and Frontiers in Integrative Neuroscience.
- Developmental cognitive neuroscience
- Assessment of developmental disabilities
Dr. Mosconi’s research examines sensorimotor, cognitive and brain development in autism spectrum and related intellectual/developmental disorders, including Phelan-McDermid Syndrome and Fragile X Syndrome. He also currently is conducting studies on neurodegenerative disorders characterized by deterioration of sensorimotor skills, such as Fragile X-associated tremor/ataxia syndrome (FXTAS). The aim of this research program is to determine the brain mechanisms that contribute to sensorimotor and cognitive impairments in developmental disorders. This knowledge then may be used for multiple purposes: 1) To identify new behavioral and brain targets for the development of more precise and effective therapeutic approaches; 2) To generate translational biobehavioral markers that can measured in clinical trials validating new treatment approaches, and; 3) To create biobehavioral measures that may assist in more reliable identification approaches for young children with autism. Dr. Mosconi’s studies integrate quantitative behavioral measurements, neuropsychological assessment, and systems neuroscience techniques including functional MRI, diffusion tensor imaging (DTI), electromyography (EMG), electroencephalography (EEG), kinematic and kinetic analysis and oculomotor recording.
- Autism, sensorimotor, cerebellum, functional MRI, EEG, child psychology, Fragile X, Phelan-McDermid Syndrome, Fragile X Associated Tremor/Ataxia Syndrome (FXTAS), repetitive behaviors, insistence on sameness, clinical psychology
Schmitt, L. M., Ankeny, L. D., Sweeney, J. A., & Mosconi, M. W. (2016). Inhibitory Control Processes and the Strategies That Support Them during Hand and Eye Movements. Frontiers in Psychology, 7, 1927. DOI:10.3389/fpsyg.2016.01927
Wang, Z. Hallac, R. R., Conroy, K. C., White, S. P., Kane, A. A., Collinsworth, A. L., Sweeney, J. A., & Mosconi, M. W. (2016). Postural orientation and equilibrium processes associated with increased postural sway in autism spectrum disorder (ASD). Journal of Neurodevelopmental Disorders, 8(43). DOI:10.1186/s11689-016-9178-1
D'Cruz, A. Mosconi, M. W., Ragozzino, M. E., Cook, E. H., & Sweeney, J. A. (2016). Alterations in the functional neural circuitry supporting flexible choice behavior in autism spectrum disorder. Translational Psychiatry, 6(10), e916. DOI:10.1038/tp.2016.161
Neely, K. A., Mohanty, S. Schmitt, L. M., Wang, Z. Sweeney, J. A., & Mosconi, M. W. (2016). Motor memory deficits contribute to motor impairments in autism spectrum disorder . Journal of Autism and Developmental Disorders. DOI:10.1007/s10803-016-2806-5
Ethridge, L. E., White, S. P., Mosconi, M. W., Wang, J. Byerly, M. J., & Sweeney, J. A. (2016). Reduced habituation of auditory evoked potentials indicated cortical hyperexcitability in Fragile X Syndrome. Translational Psychiatry, 6, e787. DOI:10.1038/tp.2016.48
Mosconi, M. W., & Lejuez, C. W. (2016). Making the brain matter in assessing and treating adolescent substance use – a commentary on Conrod and Nikolaou. Journal of Child Psychology and Psychiatry. DOI:10.1111/jcpp.12532
Ouyang, M. Cheng, H. Mishra, V. Gong, G. Mosconi, M. W., Sweeney, J. A., Peng, Y. & Huang, H. (2016). Atypical age-dependent effects of autism on white matter microstructure in children 2-7 years. Human Brain Mapping, 37(2), 819-832. DOI:10.1002/hbm.23073
Mosconi, M. W., Wang, Z. Tsai, P. T., & Sweeney, J. A. (2015). The role of cerebellar circuitry alterations in the pathophysiology of autism spectrum disorders. Frontiers in Neuroscience, 9(296). DOI:10.3389/fnins.2015.00296
Bishop, J. R., Najjar, F. Rubin, L. H., Guter, S. J., Owley, T. Mosconi, M. W., Jacob, S. & Cook, E. H. (2015). Escitalopram pharmacogenetics: CYP2C19 relationships with dosing and clinical outcomes in Autism Spectrum Disorder . Pharmacogenetics and genomics.
Najjar, F. Owley, T. Mosconi, M. W., Jacob, S. Hur, K. Guter, S. Sweeney, J. Gibbons, R. Cook, E. & Bishop, J. R. (2015). Pharmacogenetic study of serotonin transporter and 5HT2A genotypes in autism. Journal of Child and Adolescent Psychopharmacology, 467-74. DOI:10.1089/cap.2014.0158
Wang, Z. Magnon, G. C., White, S. P., Greene, R. K., Vaillancourt, D. E., & Mosconi, M. W. (2015). Individuals with autism spectrum disorder show abnormalities during initial and subsequent phases of precision gripping. Journal of Neurophysiology, 113(7), 1989-2001. DOI:10.1152/jn.00661.2014
Miller, H. L., Ragozzino, M. E., Cook, E. H., Sweeney, J. A., & Mosconi, M. W. (2015). Cognitive set shifting deficits and their relationship to repetitive behaviors in autism spectrum disorder. Journal of Autism and Developmental Disorders, 45(3), 805-15. DOI:10.1007/s10803-014-2244-1
Mosconi, M. W., Mohanty, S. Greene, R. Cook, E. H., Vaillancourt, D. E., & Sweeney, J. A. (2015). Feedforward and feedback motor control abnormalities implicate cerebellar dysfunctions in autism spectrum disorder. Journal of Neuroscience, 35(5), 2015-2025. DOI:10.1523/JNEUROSCI.2731-14.2015
Schmitt, L. M., Cook, E. H., Sweeney, J. A., & Mosconi, M. W. (2014). Saccadic eye movement abnormalities in autism spectrum disorder indicate dysfunctions in both cerebellum and brainstem. Molecular Autism, 5(1), 47. DOI:10.1186/2040-2392-5-47
Mosconi, M. W., Luna, B. Kay-Stacey, M. Nowinski, C. V., Rubin, L. H., Scudder, C. Minshew, N. & Sweeney, J. A. (2013). Saccade adaptation abnormalities implicate dysfunction of cerebellar-dependent learning mechanisms in autism spectrum disorders (ASD) . PLOS One, 8(5). DOI:10.1371/journal.pone.0063709
D’Cruz, A. M., Ragozzino, M. E., Mosconi, M. W., Cook, E. H., & Sweeney, J. A. (2013). Reduced behavioral flexibility in autism spectrum disorders is related to insistence on sameness. Neuropsychology, 27(2), 152-160. DOI:10.1037/a0031721
Mosconi, M. W., & Sweeney, J. A. (2012). Cerebellar dysfunctions underlying core cognitive and sensorimotor deficits in autism spectrum disorder. Cerebellum, 11(3), 777-807. DOI:10.1007/s12311-012-0355-9
Mosconi, M. W., Takarae, Y. & Sweeney, J. A. (2011). Motor impairments and dyspraxia in autism. In D. G. Amaral, G. Dawson, & D. H. Geschwind (Eds.), . Autism Spectrum Disorders. New York, NY: Oxford University Press, Inc.
D’Cruz, A. M., Mosconi, M. W., Ragozzino, M. E., Pavuluri, M. & Sweeney, J. A. (2011). Human reversal learning under conditions of certain versus uncertain outcomes. NeuroImage, 56, 315-322. DOI:10.1016/j.neuroimage.2011.01.068
Mosconi, M. W., Kay, M. D’Cruz, A. M., Guter, S. Kapur, K. Macmillan, C. Stanford, L. D., & Sweeney, J. A. (2010). Neurobehavioral abnormalities in first-degree relatives of individuals with autism. JAMA Psychiatry, 67, 830-840. DOI:10.1001/archgenpsychiatry.2010.87
D’Cruz, A. M., Mosconi, M. W., Steele, S. Rubin, L. Khine, T. & Sweeney, J. A. (2009). Lateralized response timing deficits in autism. Biological Psychiatry, 66, 393-397. DOI:10.1016/j.biopsych.2009.01.008
Mosconi, M. W., Hazlett, H. C., Poe, M. Gerig, G. Gimpel, R. S., & Piven, J. (2009). A longitudinal study of amygdala volume and joint attention in 2-4 year old children with autism. JAMA Psychiatry, 66, 509-516. DOI: 10.1001/archgenpsychiatry.2009.19
Huber, K., (Principal), Sweeney, J. A., (Principal), Mosconi, M. W., (Co-Investigator), Mechanisms of Neocortical and Sensory Hyperexcitability in Fragile X Syndrome, U54 Centers for Collaborative Research in Fragile X (NICHD), (09/01/2014 - 08/31/2019) . Federal. Status: Funded.
Sahin, M., (Principal), Mosconi, M. W., (Consultant), Rare Diseases Clinical Research Network: Developmental Synaptopathies Consortium, NIH/NINDS, (01/01/2014 - 08/31/2019) . Federal. Status: Funded.
Mosconi, Matthew W, (Principal), Kansas Center for Autism Research and Training Research Investment Council Strategic Initiative Grant, $750,000, (08/18/2015 - 08/17/2018) . This three year award was provided to the PI to support salary and research costs associated with starting the Neurodevelopmental Disorders Research Lab at the University of Kansas. Allowable costs include PI salary, research related expenses (e.g., equipment, MRI costs), travel, and postdoctoral and student assistant salaries. State of Kansas. Status: Funded.
Mosconi, Matthew W, (Co-Principal), Auditory and visual evoked potentials in Phelan-McDermid Syndrome, Phelan-McDermid Syndrome Foundation, (01/01/2016 - 12/31/2017) . The goal of this award is to characterize sensory evoked neurophysiological alterations in individuals with Phelan-McDermid Syndrome (PMS). Other. Status: Funded.
Versalovic, J., (Principal), Mosconi, M. W., (Co-Investigator), Establishing Multi-omic Signatures and Mechanisms Associated with GI Morbidity and Behavior in ASD, Autism Speaks, (12/01/2014 - 11/30/2017) . Private. Status: Funded.
Powell, Craig, (Co-Principal), Mosconi, Matthew W, (Consultant), Natural History Characterization of Individuals with Phelan-McDermid Syndrome, Phelan-McDermid Syndrome Foundation, (08/01/2015 - 07/31/2017) . Foundation. Status: Funded.
Mosconi, M. W., (Consultant), Neurophysiological biomarkers associated with Phelan-McDermid Syndrome, Novartis, (07/01/2015 - 06/30/2017) . For Profit (company/corporation). Status: Funded.
Mosconi, M. W., (Principal), Motor Control and Cerebellar Mechanisms in Fragile X-Associated Tremor/Ataxia Syndrome, Once Upon A Time Foundation, (09/01/2013 - 11/30/2015) . Foundation. Status: Funded.
Mosconi, M. W., (Principal), Motor Control and Cerebellar Maturation in Autism, K23 MH092696-01, NIH/NIMH, (09/01/2010 - 11/30/2015) . Federal. Status: Funded.
Sweeney, J. A., (Principal), Mosconi, M. W., (Co-Investigator), Family Studies of Neurocognitive and Sensorimotor Heterogeneity in Autism, AR100276, Dept of the Army, (09/01/2011 - 07/31/2015) . Federal. Status: Funded.
Cook, E. H., (Principal), Mosconi, M. W., (Co-Investigator), Autism Center of Excellence: Translational Studies of Insistence on Sameness in Autism, P50 HD055751-01, NICHD/NIMH, (09/01/2007 - 07/31/2013) . Federal. Status: Funded.